Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28298212 | 0.89 | MAPT (0.40) | GSK3AGSK3BTSHRUSP2CDK5 | |
| SCHEMBL28029215 | 0.85 | GSK3A (0.36) | GSK3AGSK3BKDM4ETSHRMEN1 | |
| SCHEMBL300899 | 0.77 | CSNK2A1 (0.41) | GSK3AGSK3BKDM4ETSHRMEN1 | |
| SCHEMBL28028866 | 0.74 | MAPT (0.40) | GSK3AGSK3BTSHRUSP2CDK5 | |
| SCHEMBL301294 | 0.67 | KDM4E (0.43) | GSK3AGSK3BKDM4ETSHRUSP2 | |
| SCHEMBL28155257 | 0.64 | LMNA (0.33) | LMNAMAPTALDH1A1 | |
| SCHEMBL8474128 | 0.61 | CRBN (0.43) | KDM4EUSP2CDK5CDK5R1LMNA | |
| SCHEMBL746783 | 0.61 | CRBN (0.66) | GSK3AGSK3BKDM4EMEN1KMT2A | |
| SCHEMBL11663462 | 0.60 | DDB1 (0.50) | GSK3AGSK3BKDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31439105 | 0.59 | CRBN (0.63) | GSK3AGSK3BKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109846884-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2019-06-07 | — | — | CN | disclosed |