Pyrene

Pyrene

SCHEMBL28298301

[AsH3].c1cc2ccc3cccc4ccc(c1)c2c34

nearest known ligand 0.92

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.92
HSD17B10 Q99714 6/20 0.92
TSHR P16473 6/20 0.92
HPGD P15428 4/20 0.92
CYP3A4 P08684 3/20 0.92
CYP1A2 P05177 3/20 0.92
CYP1A1 P04798 2/20 0.92
CYP1B1 Q16678 2/20 0.92
THRB P10828 1/20 0.56
TDP1 Q9NUW8 3/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
MAPK1 P28482 2/20 0.50
ATM Q13315 1/20 0.50
ERBB2 P04626 1/20 0.48
FYN P06241 1/20 0.48
MAOA P21397 1/20 0.48
ACHE P22303 1/20 0.48
AHR P35869 1/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrene SCHEMBL223412 0.96 ALDH1A1 (1.00) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL9130 0.96 ALDH1A1 (1.00) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL1650929 0.96 ALDH1A1 (1.00) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL29429699 0.96 ALDH1A1 (1.00) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL1332849 0.96 ALDH1A1 (1.00) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL23319293 0.92 ALDH1A1 (0.92) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL8161789 0.92 ALDH1A1 (0.92) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL21693735 0.92 ALDH1A1 (0.92) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL11237257 0.92 ALDH1A1 (0.92) ALDH1A1HSD17B10TSHRHPGDCYP3A4
Pyrene SCHEMBL4399830 0.92 ALDH1A1 (0.92) ALDH1A1HSD17B10TSHRHPGDCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109848194-A Ecological environment of soil restorative procedure 皖建生态环境建设有限公司 2019-06-07 CN disclosed