Urethane

Urethane

SCHEMBL28298474

CCOC(N)=O.c1ccc2c(c1)O2

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.58
TSHR P16473 2/20 0.47
POLB P06746 1/20 0.47
ATM Q13315 2/20 0.45
ALDH1A1 P00352 4/20 0.44
HSD17B10 Q99714 1/20 0.44
NPSR1 Q6W5P4 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
PKM P14618 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ALOX5 P09917 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
USP2 O75604 1/20 0.41
KDM4E B2RXH2 2/20 0.41
P2RX4 Q99571 2/20 0.41
MAPT P10636 1/20 0.41
APEX1 P27695 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urethane SCHEMBL28839463 0.85 MAOA (0.58) ALOX15TSHRPOLBATMNPSR1
Naphthalene SCHEMBL9435323 0.82 ALOX15 (0.65) ALOX15TSHRATMALDH1A1HSD17B10
Urethane SCHEMBL6557515 0.82 ALOX15 (0.65) ALOX15TSHRALDH1A1HSD17B10NPSR1
O-Xylene SCHEMBL10812881 0.82 ALOX15 (0.65) ALOX15TSHRALDH1A1HSD17B10NPSR1
Phthalic Anhydride SCHEMBL28455726 0.81 ALDH1A1 (0.59) ALOX15TSHRALDH1A1HSD17B10NPSR1
Urethane SCHEMBL1906316 0.81 ALOX15 (0.48) ALOX15TSHRATMALDH1A1HSD17B10
Toluene SCHEMBL7177102 0.80 ALOX15 (0.62) ALOX15TSHRALDH1A1HSD17B10NPSR1
Biphenyl SCHEMBL1400697 0.80 ALOX15 (0.62) ALOX15TSHRALDH1A1HSD17B10NPSR1
Catechol SCHEMBL28109933 0.80 ALOX15 (0.62) ALOX15TSHRPOLBALDH1A1HSD17B10
Urethane SCHEMBL2404606 0.79 ALOX15 (0.83) ALOX15TSHRALDH1A1HSD17B10NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110184232-A Nephrocyte group and application thereof 因瑞金公司 2019-08-30 CN disclosed
CN-104937095-B Renal cell populations and uses thereof 因瑞金公司 2019-06-07 CN disclosed