Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28298247 | 0.88 | POLB (0.60) | POLBMKNK1MKNK2KDM4EGLA | |
| SCHEMBL291601 | 0.80 | KDM4E (0.58) | KDM4EGLAHSD17B10KMT2A | |
| SCHEMBL291313 | 0.69 | KDM4E (0.58) | KDM4EGLAHSD17B10KMT2A | |
| SCHEMBL290812 | 0.68 | CSNK2A1 (0.72) | KDM4EGLAHSD17B10KMT2A | |
| SCHEMBL12764674 | 0.66 | MTOR (0.59) | MKNK1MKNK2CLK4 | |
| SCHEMBL300860 | 0.65 | KDM4E (0.46) | MKNK1MKNK2KDM4EGLAHSD17B10 | |
| SCHEMBL7682175 | 0.65 | ALDH1A1 (0.55) | KDM4EKMT2AADORA3 | |
| SCHEMBL16039069 | 0.64 | ADORA3 (0.61) | POLBKDM4EGLACYP1A2CYP3A4 | |
| SCHEMBL292619 | 0.64 | KDM4E (0.66) | KDM4EGLA | |
| SCHEMBL23830179 | 0.63 | MKNK1 (0.52) | MKNK1MKNK2CYP1A2CYP3A4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109846884-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2019-06-07 | — | — | CN | disclosed |