⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826423 | 0.86 | — | — | |
| SCHEMBL2825306 | 0.80 | — | — | |
| SCHEMBL27770403 | 0.79 | — | — | |
| SCHEMBL2824055 | 0.79 | MLYCD (0.34) | — | |
| SCHEMBL2829823 | 0.76 | MAPT (0.32) | — | |
| SCHEMBL2825355 | 0.76 | FAAH (0.38) | — | |
| SCHEMBL27956698 | 0.74 | MAPT (0.31) | — | |
| SCHEMBL967486 | 0.73 | MLYCD (0.31) | — | |
| SCHEMBL11330786 | 0.71 | — | — | |
| SCHEMBL27865861 | 0.69 | MLYCD (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | disclosed |
| US-7511038-B2 | Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors | LABORATORIOS ALMIRALL S.A. (ES) | 2009-03-31 | — | — | US | disclosed |
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | disclosed |