Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 11/20 | 0.35 |
| ▸ | JAK1 | P23458 | 11/20 | 0.35 |
| ▸ | TYK2 | P29597 | 9/20 | 0.35 |
| ▸ | JAK3 | P52333 | 6/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830138 | 0.85 | GRM5 (0.49) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL2830257 | 0.84 | GRM5 (0.50) | GRM5 | |
| SCHEMBL2826585 | 0.82 | GRM5 (0.52) | JAK2JAK3GRM5 | |
| SCHEMBL2832743 | 0.82 | SORT1 (0.34) | GRM5 | |
| SCHEMBL2826030 | 0.82 | PIK3CA (0.37) | SYK | |
| SCHEMBL2833176 | 0.81 | SORT1 (0.41) | JAK2JAK1TYK2GRM5 | |
| SCHEMBL2826529 | 0.79 | SMN1; SMN2 (0.36) | GRM5 | |
| SCHEMBL2831282 | 0.79 | NPC1 (0.43) | JAK2JAK3GRM5GSK3BDYRK1A | |
| SCHEMBL2826577 | 0.78 | RAB9A (0.37) | — | |
| SCHEMBL2829067 | 0.78 | CTSK (0.35) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |