Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.37 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31386913 | 0.77 | NOTUM (0.39) | JAK2THRBEIF4A3GPR17GPR35 | |
| SCHEMBL5953366 | 0.68 | JAK2 (0.41) | JAK2THRBEIF4A3NFKB1ALOX15 | |
| SCHEMBL21060941 | 0.67 | HCAR2 (0.38) | GPR17 | |
| SCHEMBL21060895 | 0.66 | HCAR2 (0.54) | — | |
| SCHEMBL21060982 | 0.66 | HCAR2 (0.54) | — | |
| SCHEMBL23645993 | 0.66 | HCAR2 (0.54) | — | |
| SCHEMBL31304911 | 0.62 | KEAP1 (0.37) | NFKB1ALOX15BLMSMN1; SMN2KDM4E | |
| SCHEMBL31304912 | 0.62 | KEAP1 (0.37) | NFKB1ALOX15BLMSMN1; SMN2KDM4E | |
| SCHEMBL436330 | 0.62 | NFKB1 (0.50) | GPR35NFKB1ALOX15BLMSMN1; SMN2 | |
| SCHEMBL24966986 | 0.62 | JAK2 (0.39) | JAK2THRBEIF4A3GPR17SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003188-B | Substituted pyrrole formate derivative and application thereof | 成都麻沸散医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |
| CN-110003188-A | Substituted azole formate ester derivative and application thereof | 成都安诺晨创医药科技有限公司 | 2019-07-12 | — | — | CN | disclosed |