Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicotinic Acid Hydrazide SCHEMBL258390 | 0.84 | HDAC1 (0.69) | HCAR2KDM4EALDH1A1APPGAA | |
| Nicotinic Acid Hydrazide SCHEMBL29648965 | 0.84 | HDAC1 (0.69) | HCAR2KDM4EALDH1A1APPGAA | |
| Nicotinic Acid Hydrazide SCHEMBL28127107 | 0.83 | HDAC1 (0.62) | HCAR2KDM4EALDH1A1APPGAA | |
| Nicotinic Acid Hydrazide SCHEMBL28747918 | 0.83 | HDAC1 (0.67) | HCAR2KDM4EALDH1A1APPGAA | |
| Nicotinic Acid Hydrazide SCHEMBL31491467 | 0.83 | HDAC1 (0.67) | HCAR2KDM4EALDH1A1APPGAA | |
| Benzoic Acid Hydrazide SCHEMBL5778873 | 0.80 | GAA (0.70) | HCAR2KDM4EALDH1A1APPGAA | |
| Niacinamide SCHEMBL29257530 | 0.77 | SIRT2 (0.73) | HCAR2KDM4ENAPRTALDH1A1APP | |
| Nicotinic Acid Hydrazide SCHEMBL28112815 | 0.77 | HDAC1 (0.59) | HCAR2KDM4EALDH1A1APPGAA | |
| Isoniazid SCHEMBL2473355 | 0.77 | KDM4E (0.64) | HCAR2KDM4ENAPRTALDH1A1GAA | |
| Pyrazine Carboxylic Acid Hydrazide SCHEMBL107341 | 0.76 | ADORA3 (0.61) | HCAR2KDM4ENAPRTHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764514-B | Aminopyridine derivatives as inhibitors of TAM family kinases | 圣诺康生命科学公司 | 2019-07-12 | — | — | CN | disclosed |