SCHEMBL28305166

SCHEMBL28305166

Brc1ccc(-c2cccc(-c3nnco3)c2)cc1

nearest known ligand 0.73

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 13/20 0.58
ALDH1A1 P00352 2/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
MEN1 O00255 1/20 0.50
CYP1A2 P05177 1/20 0.50
KMT2A Q03164 1/20 0.50
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
KDM4E B2RXH2 1/20 0.47
LMNA P02545 1/20 0.47
TSHR P16473 1/20 0.47
TLR8 Q9NR97 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11232897 0.86 NOTUM (0.74) NOTUMALDH1A1HPGDMAPK1KDM4E
SCHEMBL21795694 0.86 NOTUM (0.75) NOTUMALDH1A1HPGDMAPK1KDM4E
SCHEMBL1016310 0.84 NOTUM (0.64) NOTUMALDH1A1NPC1RAB9AMEN1
SCHEMBL1194538 0.84 NOTUM (0.64) NOTUMALDH1A1NPC1RAB9AKMT2A
Methane SCHEMBL28263281 0.82 NOTUM (0.62) NOTUMALDH1A1NPC1RAB9AKMT2A
SCHEMBL5571187 0.76 NOTUM (0.91) NOTUMALDH1A1KDM4ELMNATSHR
SCHEMBL2610163 0.75 NOTUM (0.75) NOTUMALDH1A1HPGDMAPK1KDM4E
SCHEMBL12619988 0.75 ALDH1A1 (0.68) ALDH1A1NPC1RAB9AMEN1CYP1A2
SCHEMBL3946608 0.75 ALDH1A1 (0.68) ALDH1A1NPC1RAB9AMEN1CYP1A2
SCHEMBL20385206 0.75 NPC1 (0.75) ALDH1A1NPC1RAB9AMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108039422-B Electron transport material and preparation method applied to solution processing type organic electroluminescence device 天津大学 2019-07-09 CN disclosed