Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diaminopyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 3/20 | 0.45 |
| ▸ | GABRD | O14764 | 3/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.45 |
| ▸ | GABRE | P78334 | 3/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diaminopyrimidine SCHEMBL28306270 | 1.00 | GABRP (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Diaminopyrimidine SCHEMBL27649689 | 0.93 | GABRP (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Diaminopyrimidine SCHEMBL4611091 | 0.93 | GABRP (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Diaminopyrimidine SCHEMBL27780033 | 0.91 | GABRP (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Diaminopyrimidine SCHEMBL28220186 | 0.89 | ROCK1 (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Diaminopyrimidine SCHEMBL6013998 | 0.88 | HSP90AA1 (0.48) | HSP90AA1AURKAPRKACAADORA2AROCK1 | |
| Diaminopyrimidine SCHEMBL29389172 | 0.88 | — | — | |
| Diaminopyrimidine SCHEMBL53016 | 0.88 | — | — | |
| Cadaverine Tartrate SCHEMBL18795887 | 0.86 | GABRP (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Diaminopyrimidine SCHEMBL1290828 | 0.86 | L3MBTL1 (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890816-A | novel pyrimidine derivatives having antimalarial activity | 卡尔那生物科学株式会社 | 2019-06-14 | — | — | CN | disclosed |