Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11096498 | 0.81 | MEN1 (0.40) | CYP2C9MEN1KMT2AHDAC4OPRM1 | |
| Iodide SCHEMBL11093787 | 0.79 | MEN1 (0.39) | CYP2C9MEN1KMT2AHDAC4OPRM1 | |
| SCHEMBL11094080 | 0.79 | GRIN1 (0.45) | CYP2C9MEN1KMT2AHDAC4OPRM1 | |
| SCHEMBL9729622 | 0.78 | MEN1 (0.53) | CYP2C9MEN1KMT2AHDAC4OPRM1 | |
| SCHEMBL11096692 | 0.78 | CYP2D6 (0.42) | CYP2C9MEN1KMT2AHDAC4OPRM1 | |
| Ethylene SCHEMBL11093850 | 0.78 | MEN1 (0.38) | CYP2C9MEN1KMT2AHDAC4OPRM1 | |
| SCHEMBL11096483 | 0.77 | SLC6A3 (0.47) | CYP2C9MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL6952827 | 0.75 | OPRM1 (0.50) | CYP2C9MEN1KMT2AHDAC4OPRM1 | |
| SCHEMBL17982791 | 0.75 | MEN1 (0.41) | CYP2C9MEN1KMT2AHDAC4PSEN1 | |
| SCHEMBL11559606 | 0.75 | HDAC4 (0.41) | CYP2C9MEN1KMT2AHDAC4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233487-A1 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |