Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 3/20 | 0.50 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13055402 | 0.87 | CYP17A1 (0.59) | CYP17A1PSMB8NAMPTCA12CA1 | |
| SCHEMBL2831546 | 0.84 | HDAC3 (0.51) | CYP17A1NAMPTCA12CA1CA9 | |
| SCHEMBL418939 | 0.83 | CYP17A1 (0.54) | CYP17A1PSMB8NAMPTCA12CA1 | |
| SCHEMBL14861049 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL23619661 | 0.82 | SMN1; SMN2 (0.62) | CYP17A1PSMB8NAMPTCA12CA1 | |
| SCHEMBL20865536 | 0.82 | CYP17A1 (0.68) | CYP17A1PSMB8NAMPTCA12CA1 | |
| SCHEMBL21021336 | 0.81 | CA12 (0.50) | CYP17A1PSMB8NAMPTCA12CA1 | |
| SCHEMBL437131 | 0.80 | CYP17A1 (0.54) | CYP17A1PSMB8NAMPTCA12CA1 | |
| SCHEMBL11925396 | 0.80 | SMN1; SMN2 (0.66) | CYP17A1PSMB8NAMPTCA12CA1 | |
| SCHEMBL977487 | 0.80 | CYP17A1 (0.54) | CYP17A1PSMB8NAMPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9862675-B1 | Method of N-formylating amines with a phosphonic anhydride | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2018-01-09 | — | — | US | disclosed |
| US-7655640-B2 | Camptothecin analogs and methods of preparation thereof | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-02-02 | — | — | US | disclosed |
| US-7514418-B2 | Camptothecin analogs and methods of preparation thereof | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2009-04-07 | — | — | US | disclosed |
| EP-1017399-B1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIV PITTSBURGH (US) | 2008-12-24 | — | — | EP | disclosed |
| US-20080269169-A1 | Camptothecin analogs and methods of preparation thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-10-30 | — | — | US | disclosed |
| EP-1140948-A4 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIV PITTSBURGH (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20070259905-A1 | Camptothecin analogs and methods of preparation thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-08 | — | — | US | disclosed |
| US-7271159-B2 | Camptothecin analogs and methods of preparation thereof | UNIVERSITY OF PITTSBURGH (US) | 2007-09-18 | — | — | US | disclosed |
| US-6743917-B2 | 7-(TRIALKYLSILYLALKYL)-CAMPTOTHECIN OF GIVEN FORMULA BY CYCLIZING A 4-HYDROXY-6-HALO,7-(TRIALKYLSILYLALKYL)-3,4,7,8-TETRAHYDRO-1H-PYRANO(3,4 -C)PYRIDIN-3,8-DIONE WITH AN ARYL ISONITRILE | UNIVERSITY OF PITTSBURGH | 2004-06-01 | — | — | US | disclosed |
| US-20040029835-A1 | Camptothecin analogs and methods of preparation thereof | UNIVERSITY OF PITTSBURGH | 2004-02-12 | — | — | US | disclosed |
| US-20030105324-A1 | Camptothecin analogs and methods of preparation thereof | CURRAN DENNIS P (US) | 2003-06-05 | — | — | US | disclosed |
| US-20020193598-A1 | Camptothecin analogs and methods of preparation thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-12-19 | — | — | US | disclosed |
| US-6455699-B1 | SUCH AS (20S)10-HYDROXY-7-TERT-BUTYLDIMETHYLSILYL-CAMPHTOTHECIN; ANTITUMOR AGENTS; SOLUBILITY; BIOAVAILABILITY/ BIODISTRIBUTION | UNIVERSITY OF PITTSBURGH | 2002-09-24 | — | — | US | disclosed |
| EP-1140948-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6150343-A | 10-HYDROXY-7-SUBSTITUTED SILYLCAMPTOTHECIN DERIVATIVE IS USED AS ANTICARCINOGENIC AND ANTITUMOR AGENT | UNIVERSITY OF PITTSBURGH (US) | 2000-11-21 | — | — | US | disclosed |
| US-6136978-A | CYCLIZING SILYL COMPOUND WITH ARYL ISONITRILE COMPOUND TO FORM SILYL CAMPTOTHECIN DERIVATIVE | UNIVERSITY OF PITTSBURGH (US) | 2000-10-24 | — | — | US | disclosed |
| WO-2000035924-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193598-A1 | Camptothecin analogs and methods of preparation thereof | TOP1, TOP2A, TOP2B | CYP17A1 359/4885PSMB8 2844/4885NAMPT 3692/4885 |
| US-20070259905-A1 | Camptothecin analogs and methods of preparation thereof | ADCY9, BCL9, ADCY10 | CYP17A1 706/4885PSMB8 3255/4885NAMPT 1514/4885 |
| US-20030105324-A1 | Camptothecin analogs and methods of preparation thereof | HCCS, ADCY10, TOP2A | CYP17A1 582/4885PSMB8 3365/4885NAMPT 2931/4885 |
| US-20080269169-A1 | Camptothecin analogs and methods of preparation thereof | TOP2A, TOP1, TOP2B | CYP17A1 418/4885PSMB8 2396/4885NAMPT 407/4885 |
| US-20040029835-A1 | Camptothecin analogs and methods of preparation thereof | HCCS, ADCY10, TOP2A | CYP17A1 582/4885PSMB8 3365/4885NAMPT 2931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.