SCHEMBL28309130

SCHEMBL28309130

Cc1nc(-c2nccc(N)c2C)c(C)c(N)c1C

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
IRAK4 Q9NWZ3 1/20 0.36
NOS3 P29474 3/20 0.35
NOS2 P35228 3/20 0.35
CYP3A4 P08684 1/20 0.32
TSHR P16473 1/20 0.32
PIK3CA P42336 1/20 0.32
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
NOS1 P29475 1/20 0.31
KMT2A Q03164 1/20 0.31
LMNA P02545 1/20 0.31
MMP12 P39900 1/20 0.31
CDK4 P11802 1/20 0.30
CCNE1 P24864 1/20 0.30
CDK2 P24941 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL35248 0.71
SCHEMBL29626655 0.71
SCHEMBL18957021 0.69 CDK5 (0.45) IRAK4CYP3A4TSHRPIK3CAKDM4E
SCHEMBL28273560 0.69 NOS2 (0.44) NOS3NOS2CYP3A4TSHRPIK3CA
Hydrochloric Acid SCHEMBL9013637 0.69 NOS2 (0.44) NOS3NOS2CYP3A4TSHRPIK3CA
Hydrochloric Acid SCHEMBL7421394 0.69 NOS2 (0.44) NOS3NOS2CYP3A4TSHRPIK3CA
SCHEMBL352526 0.67 ASIC3 (0.47) IRAK4NOS3NOS2CYP3A4TSHR
SCHEMBL29593111 0.66
SCHEMBL30711660 0.66
SCHEMBL373587 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109824465-A A kind of method of bipyridyliums Mn catalyst catalysis oxidation amine synthesizing amide 陕西师范大学 2019-05-31 CN claimed
CN-107501314-B The method of bipyridyliums Mn catalyst catalysis oxidation silane synthesis silanol 陕西师范大学 2019-08-20 CN disclosed
CN-109824465-A A kind of method of bipyridyliums Mn catalyst catalysis oxidation amine synthesizing amide 陕西师范大学 2019-05-31 CN disclosed