Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28141071 | 0.86 | LMNA (0.52) | MAPTLMNAALDH1A1HPGDHTT | |
| SCHEMBL28141074 | 0.84 | ALDH1A1 (0.57) | LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL28141066 | 0.82 | ALDH1A1 (0.59) | LMNAALDH1A1HPGDL3MBTL1ATM | |
| SCHEMBL28309753 | 0.81 | MEN1 (0.59) | MAPTLMNAALDH1A1HPGDL3MBTL1 | |
| SCHEMBL12354776 | 0.79 | LTA4H (0.60) | LMNAALDH1A1HPGD | |
| SCHEMBL28141070 | 0.78 | ALDH1A1 (0.61) | LMNAALDH1A1HPGDL3MBTL1KMT2A | |
| SCHEMBL11958216 | 0.78 | PTPN1 (0.51) | MAPTALDH1A1 | |
| SCHEMBL13724165 | 0.77 | EPHX2 (0.61) | LMNAALDH1A1EPHX2L3MBTL1KMT2A | |
| SCHEMBL2094723 | 0.76 | EPHX2 (0.66) | LMNAALDH1A1EPHX2L3MBTL1MTOR | |
| SCHEMBL853366 | 0.76 | HTT (0.56) | MAPTLMNAALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632092-B | A kind of 1,3- dimethyl -7- substituted quinazoline -2,4- cyclohexadione compounds and its synthetic method and application | 重庆智合生物医药有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-106632092-A | 1,3-dimethyl-7-substituted-quinazolinyl-2,4-diones, and synthesis method and application thereof | 重庆智合生物医药有限公司 | 2017-05-10 | — | — | CN | disclosed |