Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826783 | 0.91 | GRM5 (0.49) | GRM5PORCNSMARCA2SMARCA4GPR142 | |
| SCHEMBL2829074 | 0.88 | GRM5 (0.47) | GRM5PORCNSMARCA2SMARCA4GPR142 | |
| SCHEMBL2824749 | 0.85 | MET (0.42) | GRM5KDM1AMAOBRCOR1CYP3A4 | |
| SCHEMBL2829130 | 0.85 | GRM5 (0.51) | GRM5PORCNSMARCA2SMARCA4MEN1 | |
| SCHEMBL2826236 | 0.83 | GRM5 (0.49) | GRM5ROCK1 | |
| SCHEMBL2826248 | 0.83 | SMARCA2 (0.56) | GRM5PORCNSMARCA2SMARCA4NPC1 | |
| SCHEMBL2828966 | 0.83 | GRM5 (0.40) | GRM5SMARCA2SMARCA4CYP3A4ALDH1A1 | |
| SCHEMBL2829701 | 0.83 | GRM5 (0.48) | GRM5PORCNMEN1NPC1RAB9A | |
| SCHEMBL2830980 | 0.83 | GRM5 (0.48) | GRM5MEN1KMT2AKDR | |
| SCHEMBL2832391 | 0.82 | GRM5 (0.38) | GRM5KDM1AMAOBRCOR1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |