Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.58 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830357 | 0.90 | TRPA1 (0.58) | TRPA1TRPV4MGLLKMT2AMAPT | |
| SCHEMBL2825544 | 0.89 | MAPT (0.64) | MGLLKMT2AMAPTNPSR1ALDH1A1 | |
| SCHEMBL2826777 | 0.87 | NPSR1 (0.66) | TRPA1TRPV4MGLLKMT2AMAPT | |
| SCHEMBL2829180 | 0.87 | MAPT (0.60) | MGLLKMT2AMAPTNPSR1GAA | |
| SCHEMBL2827972 | 0.87 | MAPT (0.59) | TRPA1MGLLKMT2AMAPTNPSR1 | |
| SCHEMBL2825667 | 0.85 | SMN1; SMN2 (0.63) | MGLLKMT2AMAPTNPSR1ALDH1A1 | |
| SCHEMBL2827630 | 0.85 | SMN1; SMN2 (0.59) | MGLLKMT2AMAPTGAAALDH1A1 | |
| SCHEMBL2829892 | 0.84 | PIK3C2A (0.52) | TRPA1MGLLKMT2AMAPTNPSR1 | |
| SCHEMBL2827614 | 0.83 | HDAC1 (0.56) | MGLLKMT2AMAPTNPSR1POLB | |
| SCHEMBL2826708 | 0.83 | ABL1 (0.57) | TRPA1MGLLKMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948650-B1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES USEFUL IN TREATMENT OF TRPV1 RELATED DISORDERS | ORGANON NV (NL) | 2010-05-26 | — | — | EP | claimed |
| US-20100099722-A1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES | MSD OSS B.V. (NL) | 2010-04-22 | — | — | US | claimed |
| EP-1948650-A1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES USEFUL IN TREATMENT OF TRPV1 RELATED DISORDERS | N.V. Organon (NL) | 2008-07-30 | — | — | EP | claimed |
| WO-2007054474-A1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES USEFUL IN TREATMENT OF TRPV1 RELATED DISORDERS | N.V. ORGANON (NL) | 2007-05-18 | — | — | WO | claimed |
| US-20070105920-A1 | 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives | AKZO NOBEL N.V. (NL) | 2007-05-10 | — | — | US | claimed |
| EP-1948650-B1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES USEFUL IN TREATMENT OF TRPV1 RELATED DISORDERS | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |
| US-20100099722-A1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES | MSD OSS B.V. (NL) | 2010-04-22 | — | — | US | disclosed |
| EP-1948650-A1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES USEFUL IN TREATMENT OF TRPV1 RELATED DISORDERS | N.V. Organon (NL) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054474-A1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES USEFUL IN TREATMENT OF TRPV1 RELATED DISORDERS | N.V. ORGANON (NL) | 2007-05-18 | — | — | WO | disclosed |
| US-20070105920-A1 | 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives | AKZO NOBEL N.V. (NL) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105920-A1 | 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives | TRPV1, TRPV3, TRPV4 | TRPA1 4/4885TRPV4 3/4885MGLL 3317/4885 |
| US-20100099722-A1 | 2-(BENZIMIDAZOL-1-YL)-N-(4-PHENYLTHIAZOL-2-YL) ACETAMIDE DERIVATIVES | TRPV1, TRPV3, TRPA1 | TRPA1 3/4885TRPV4 4/4885MGLL 3352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.