Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829129 | 0.83 | GRM5 (0.41) | GRM5KMT2AMEN1 | |
| SCHEMBL2830060 | 0.82 | ALDH1A1 (0.38) | ALDH1A1PKMGRM5KMT2A | |
| SCHEMBL2828411 | 0.78 | ADORA1 (0.43) | ALDH1A1GRM5KMT2AMEN1 | |
| SCHEMBL2832249 | 0.78 | MAPT (0.37) | ALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL2827603 | 0.78 | LMNA (0.33) | GRM5KMT2A | |
| SCHEMBL2827654 | 0.78 | GRM5 (0.38) | ALDH1A1PKMGRM5NTRK1 | |
| SCHEMBL2826716 | 0.78 | GRM5 (0.50) | GRM5KMT2AMEN1 | |
| SCHEMBL2830074 | 0.78 | CSNK2A1 (0.38) | GRM5 | |
| SCHEMBL2830759 | 0.77 | SMARCA2 (0.43) | GRM5KMT2A | |
| SCHEMBL2831219 | 0.76 | NPC1 (0.37) | ALDH1A1GRM5NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |