Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | SMO | Q99835 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030554 | 0.87 | SIGMAR1 (0.62) | MAPTSIGMAR1ALDH1A1PKMKDM4E | |
| SCHEMBL6030381 | 0.87 | ALDH1A1 (0.72) | MAPTLMNASIGMAR1MAPK1ALDH1A1 | |
| SCHEMBL7991490 | 0.86 | SIGMAR1 (0.69) | L3MBTL1SIGMAR1DRD2 | |
| SCHEMBL18177898 | 0.86 | MAPT (0.65) | MAPTL3MBTL1SIGMAR1MAPK1KDM4E | |
| Bromide SCHEMBL6578060 | 0.85 | ALDH1A1 (0.71) | MAPTLMNASIGMAR1MAPK1ALDH1A1 | |
| Bromide SCHEMBL6579961 | 0.85 | SIGMAR1 (0.60) | MAPTSIGMAR1ALDH1A1PKMKDM4E | |
| SCHEMBL5542061 | 0.85 | SIGMAR1 (0.60) | MAPTL3MBTL1SIGMAR1MAPK1ALDH1A1 | |
| SCHEMBL5542069 | 0.85 | DRD4 (0.66) | MAPTL3MBTL1LMNASIGMAR1ALDH1A1 | |
| SCHEMBL11549500 | 0.85 | SIGMAR1 (0.60) | MAPTL3MBTL1LMNASIGMAR1ALDH1A1 | |
| SCHEMBL11923385 | 0.85 | SIGMAR1 (0.79) | MAPTSMOL3MBTL1LMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105873915-B | For treating the compound of mental illness | BRISTOL-MYERS SQUIBB CO. (US) | 2019-07-16 | — | — | CN | disclosed |