Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 8/20 | 0.50 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 8/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | ADH1B | P00325 | 4/20 | 0.45 |
| ▸ | ADH1A | P07327 | 4/20 | 0.45 |
| ▸ | ADH1C | P00326 | 3/20 | 0.42 |
| ▸ | ADH7 | P40394 | 2/20 | 0.42 |
| ▸ | ADH4 | P08319 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28267489 | 0.95 | GNAO1 (0.56) | GNAI3GNAO1GNAI1EPHX1EPHX2 | |
| SCHEMBL4684725 | 0.84 | ADH1B (0.46) | GNAI3GNAO1GNAI1EPHX1EPHX2 | |
| Hydrochloric Acid SCHEMBL28625285 | 0.82 | GNAO1 (0.55) | GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL28635747 | 0.82 | GNAO1 (0.55) | GNAI3GNAO1GNAI1 | |
| SCHEMBL3954245 | 0.82 | ADH1B (0.45) | GNAI3GNAO1GNAI1EPHX1EPHX2 | |
| SCHEMBL28747657 | 0.81 | BRD4 (0.41) | GNAI3GNAO1GNAI1ADH1BADH1A | |
| SCHEMBL1781920 | 0.81 | ADH1B (0.52) | EPHX1EPHX2ADH1BADH1AADH1C | |
| SCHEMBL172647 | 0.79 | ADH1B (0.40) | GNAI3GNAO1GNAI1EPHX1EPHX2 | |
| SCHEMBL1307156 | 0.78 | ADH1B (0.48) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL1781486 | 0.77 | KDM1A (0.45) | ADH1BADH1AADH1CADH7ADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-A | Pyrazolo [1,5-A] pyridine compounds being substituted are as RET kinase inhibitor | 阿雷生物药品公司 | 2019-08-27 | — | — | CN | disclosed |