Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.51 |
| ▸ | IDH2 | P48735 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.49 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.49 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28845311 | 0.80 | MPO (0.58) | EPHX2GRIK1IDH2MEN1KMT2A | |
| SCHEMBL28845310 | 0.79 | KCNK3 (0.56) | EPHX2GRIK1MEN1KMT2AMAPT | |
| SCHEMBL28317989 | 0.74 | EPHX2 (0.57) | EPHX2GRIK1IDH2MEN1KMT2A | |
| SCHEMBL17664319 | 0.73 | KMT2A (0.82) | GRIK1MEN1KMT2AMAPTHTT | |
| SCHEMBL24513148 | 0.72 | ADRA2A (0.56) | EPHX2IDH2MEN1KMT2AMAPT | |
| SCHEMBL19403890 | 0.72 | MAPT (0.81) | EPHX2MEN1KMT2AMAPTHTT | |
| SCHEMBL2752512 | 0.72 | EPHX2 (0.97) | EPHX2MEN1KMT2AMAPTHTT | |
| SCHEMBL10943481 | 0.71 | EPHX2 (1.00) | EPHX2MEN1KMT2AMAPTHTT | |
| SCHEMBL11440381 | 0.71 | MAPT (0.73) | GRIK1MEN1KMT2AMAPTHTT | |
| SCHEMBL28876142 | 0.71 | IDH2 (0.66) | EPHX2IDH2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106810512-B | IDH2 mutant inhibitor and application thereof | 江苏省中医药研究院 | 2019-09-10 | — | — | CN | disclosed |
| CN-106810512-A | IDH2 mutant inhibitor and application thereof | 江苏省中医药研究院 | 2017-06-09 | — | — | CN | disclosed |