Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | MAOA | P21397 | 9/20 | 0.61 |
| ▸ | MAOB | P27338 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19180463 | 0.88 | MAPT (0.67) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL19180460 | 0.88 | MAPT (0.67) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL177572 | 0.81 | PTPN1 (1.00) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL8870028 | 0.81 | PTPN1 (0.62) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL19196841 | 0.77 | ALDH1A1 (0.56) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL19182262 | 0.77 | ALDH1A1 (0.56) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL19182080 | 0.77 | ALDH1A1 (0.56) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL19182079 | 0.77 | ALDH1A1 (0.56) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL19182263 | 0.77 | ALDH1A1 (0.56) | ALDH1A1PTPN1HTTMAOAMAOB | |
| SCHEMBL12325876 | 0.77 | MAPT (0.65) | ALDH1A1PTPN1HTTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114790213-A | Synthetic method of spiro [ indazole-isoxazole ] derivative applied to methoxyphenyl substituted chromone-containing structure | 徐诺药业(南京)有限公司 | 2022-07-26 | — | — | CN | claimed |
| CN-110143971-B | Methylthiophenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2021-04-30 | — | — | CN | claimed |
| CN-110128446-B | 3,4, 5-trimethoxy phenyl substituted spiro [ indazole-isoxazole ] derivative containing chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2021-02-09 | — | — | CN | claimed |
| CN-110183467-B | P-methoxyphenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2020-12-08 | — | — | CN | claimed |
| CN-110128445-B | P-chlorophenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2020-12-08 | — | — | CN | claimed |
| CN-110128447-B | P-methylphenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2020-11-13 | — | — | CN | claimed |
| CN-110256462-B | Para-fluorophenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2020-11-13 | — | — | CN | claimed |
| CN-110128444-B | P-nitrophenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2020-11-13 | — | — | CN | claimed |
| CN-110156812-B | Spiro [ indazole-isoxazole ] derivative containing chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2020-09-11 | — | — | CN | claimed |
| CN-114790213-A | Synthetic method of spiro [ indazole-isoxazole ] derivative applied to methoxyphenyl substituted chromone-containing structure | 徐诺药业(南京)有限公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-114790213-A | Synthetic method of spiro [ indazole-isoxazole ] derivative applied to methoxyphenyl substituted chromone-containing structure | 徐诺药业(南京)有限公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-110143971-B | Methylthiophenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2021-04-30 | — | — | CN | disclosed |
| CN-110143971-B | Methylthiophenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2021-04-30 | — | — | CN | disclosed |
| CN-110128446-B | 3,4, 5-trimethoxy phenyl substituted spiro [ indazole-isoxazole ] derivative containing chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2021-02-09 | — | — | CN | disclosed |
| CN-110128447-B | P-methylphenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2020-11-13 | — | — | CN | disclosed |
| CN-110128447-B | P-methylphenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2020-11-13 | — | — | CN | disclosed |
| CN-110156812-B | Spiro [ indazole-isoxazole ] derivative containing chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2020-09-11 | — | — | CN | disclosed |
| CN-110156812-B | Spiro [ indazole-isoxazole ] derivative containing chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2020-09-11 | — | — | CN | disclosed |
| CN-110183467-A | P-methoxyphenyl substituted chromone structure-containing spiro [ indazole-isoxazole ] derivative, and preparation method and application thereof | 绍兴文理学院 | 2019-08-30 | — | — | CN | disclosed |
| CN-110128446-A | 3,4, 5-trimethoxy phenyl substituted spiro [ indazole-isoxazole ] derivative containing chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2019-08-16 | — | — | CN | disclosed |