Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 8/20 | 0.61 |
| ▸ | MAOB | P27338 | 8/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28318700 | 0.81 | ALDH1A1 (0.70) | PTPN1MAOAMAOBHTTMAPT | |
| SCHEMBL12325876 | 0.78 | MAPT (0.65) | PTPN1MAOAMAOBHTTMAPT | |
| SCHEMBL177572 | 0.77 | PTPN1 (1.00) | PTPN1MAOAMAOBHTTMAPT | |
| SCHEMBL8870024 | 0.72 | GRIN1 (0.49) | MAOACA12CA1CA2CA9 | |
| SCHEMBL27839334 | 0.72 | SMN1; SMN2 (0.67) | PTPN1MAOAMAOBHTTCA12 | |
| SCHEMBL19180460 | 0.70 | MAPT (0.67) | PTPN1MAOAMAOBPTGS2HTT | |
| SCHEMBL19180463 | 0.70 | MAPT (0.67) | PTPN1MAOAMAOBPTGS2HTT | |
| SCHEMBL15951253 | 0.69 | PTPN1 (0.78) | PTPN1MAOAMAOBHTTMAPT | |
| SCHEMBL8869586 | 0.68 | MAOB (0.58) | PTPN1MAOAMAOBHTTCA12 | |
| SCHEMBL13856191 | 0.68 | MAPT (0.74) | PTPN1MAOAMAOBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607928-A | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives | ZENECA LIMITED (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0695753-A1 | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use | ZENECA LIMITED (GB) | 1996-02-07 | — | — | EP | disclosed |