Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL791659 | 0.87 | KMT2A (0.71) | KDM4EPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL2830318 | 0.85 | POLB (0.76) | ACHEKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL2829558 | 0.84 | ACHE (0.60) | ACHEKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL3776056 | 0.83 | KMT2A (0.57) | ACHEKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL2829296 | 0.82 | KDM4E (0.62) | ACHEKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL2830956 | 0.82 | CYP2D6 (0.64) | ACHEKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL2829771 | 0.81 | ACHE (0.73) | ACHEKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL2832017 | 0.80 | MEN1 (0.61) | ACHEKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL2830939 | 0.80 | KMT2A (0.58) | ACHEKDM4EPOLBTDP1KMT2A | |
| SCHEMBL5456813 | 0.77 | ALDH1A1 (0.64) | KDM4ECYP2D6CYP2C19NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |