Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379135 | 0.90 | ALDH1A1 (0.73) | ACHEKDM4EALDH1A1ORAI1POLB | |
| SCHEMBL4384069 | 0.88 | ALDH1A1 (0.71) | ACHEKDM4EALDH1A1ORAI1POLB | |
| SCHEMBL2829286 | 0.87 | ACHE (0.69) | ACHEKDM4EALDH1A1ORAI1CYP2D6 | |
| SCHEMBL2836569 | 0.87 | ACHE (0.72) | ACHEKDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL182672 | 0.84 | ACHE (0.68) | ACHEKDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL2828800 | 0.84 | ACHE (0.67) | ACHEKDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL3767766 | 0.83 | ACHE (0.68) | ACHEKDM4EALDH1A1ORAI1POLB | |
| SCHEMBL2833225 | 0.82 | KMT2A (0.80) | ACHEKDM4EALDH1A1FKBP1ATDP1 | |
| SCHEMBL2832012 | 0.81 | ACHE (0.64) | ACHEKDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL2831262 | 0.81 | NPC1 (0.76) | ACHEKDM4EALDH1A1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |