Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | RECQL | P46063 | 2/20 | 0.79 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.79 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.79 |
| ▸ | F3 | P13726 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | TNKS | O95271 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL1367016 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL2128854 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL1827856 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL7629150 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL2128849 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL84057 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL18788602 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL28370740 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL29371090 | 1.00 | CYP1A2 (0.79) | CYP1A2CYP2C9MAPTPLIN1LMNA | |
| Chloroform SCHEMBL1043119 | 0.98 | CYP1A2 (0.83) | CYP1A2CYP2C9MAPTPLIN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | disclosed |
| US-7678815-B2 | Thiazole-4-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2006-07-20 | — | — | US | disclosed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | disclosed |
| EP-1084105-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1084124-A4 | BENZOTHIAZOLYTHIOMETHYL CARBAPENEM ANTIBACTERIAL | MERCK & CO INC (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-1086104-A4 | FUSED PHENOXYMETHYL CARBAPENEM ANTIBACTERIALS | MERCK & CO INC (US) | 2002-02-06 | — | — | EP | disclosed |
| US-6310055-B2 | CARBAPENEM NUCLEUS 2-SUBSTITUTED WITH A HALOPHENOXY LINKED THROUGH AN UNSATURATED GROUP, AND FURTHER INCLUDES AT LEAST ONE AMINE SALT OR QUATERNARY AMMONIUM GROUP; WORKS AGAINST GRAMPOSITIVE METHICILLIN RESISTANT BACTERIA | MERCK & CO., INC. | 2001-10-30 | — | — | US | disclosed |
| US-6288054-B1 | ANTIBIOTIC RESISTANT STAPHYLOCOCCUS; GRAMPOSITIVE BACTERIA | MERCK & CO., INC. | 2001-09-11 | — | — | US | disclosed |
| US-20010020018-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. | 2001-09-06 | — | — | US | disclosed |
| US-6284753-B2 | GRAMPOSITVE BACTERIA | MERCK & CO., INC. | 2001-09-04 | — | — | US | disclosed |
| US-20010011086-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. | 2001-08-02 | — | — | US | disclosed |
| EP-1086104-A1 | FUSED PHENOXYMETHYL CARBAPENEM ANTIBACTERIALS | Merck & Co., Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| EP-1084105-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-1084124-A1 | BENZOTHIAZOLYTHIOMETHYL CARBAPENEM ANTIBACTERIAL | Merck & Co., Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062906-A1 | BENZOTHIAZOLYTHIOMETHYL CARBAPENEM ANTIBACTERIAL | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999062907-A1 | FUSED PHENOXYMETHYL CARBAPENEM ANTIBACTERIALS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999062878-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020018-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | TOP1, NRDC, PAICS | CYP1A2 3157/4885CYP2C9 1300/4885MAPT 4547/4885 |
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | GRM1, GRM2, GRIA4 | CYP1A2 3078/4885CYP2C9 2618/4885MAPT 3444/4885 |
| US-20010011086-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | TOP1, NRDC, PAICS | CYP1A2 3157/4885CYP2C9 1300/4885MAPT 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.