SCHEMBL28320282

SCHEMBL28320282

O=COCc1cc(OCc2ccccc2)ccn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.50
MAOA P21397 2/20 0.50
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
ALDH1A1 P00352 2/20 0.48
LNPEP Q9UIQ6 1/20 0.46
CCNB2 O95067 1/20 0.46
CDK1 P06493 1/20 0.46
CDK4 P11802 1/20 0.46
CCNB1 P14635 1/20 0.46
CCND1 P24385 1/20 0.46
CCNB3 Q8WWL7 1/20 0.46
ALOX5 P09917 1/20 0.45
CYP3A4 P08684 1/20 0.44
BCHE P06276 1/20 0.44
NSD2 O96028 1/20 0.43
ABL1 P00519 1/20 0.43
PPARG P37231 1/20 0.43
RIN1 Q13671 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5538047 0.78 MAOB (0.64) MAOBMAOAALDH1A1CCNB2CDK1
SCHEMBL1932255 0.78 ALOX5 (0.50) MAOBMAOAMEN1KMT2AALDH1A1
SCHEMBL1932252 0.78 CYP4F2 (0.53) MAOBMAOAMEN1KMT2AALDH1A1
SCHEMBL30931669 0.78 MAOB (0.53) MAOBMAOAMEN1KMT2AALDH1A1
SCHEMBL1931475 0.78 MAOB (0.53) MAOBMAOAMEN1KMT2AALDH1A1
SCHEMBL29992952 0.78 CYP4F2 (0.53) MAOBMAOAMEN1KMT2AALDH1A1
SCHEMBL7284511 0.78 NOS2 (0.54) ALDH1A1PLAUKDM4E
SCHEMBL29992466 0.77 MAOB (0.58) MAOBMAOAMEN1KMT2AALDH1A1
SCHEMBL19859637 0.77 MAOB (0.58) MAOBMAOAMEN1KMT2AALDH1A1
Hydrochloric Acid SCHEMBL18686893 0.77 MEN1 (0.51) MAOBMAOAMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110143949-A Novel heterocyclic derivatives useful as SHP2 inhibitors 北京加科思新药研发有限公司 2019-08-20 CN disclosed