Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 7/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18686893 | 0.98 | MEN1 (0.51) | ALOX5MEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL29992952 | 0.83 | CYP4F2 (0.53) | ALOX5MEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL1932252 | 0.83 | CYP4F2 (0.53) | ALOX5MEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL1931475 | 0.83 | MAOB (0.53) | ALOX5MEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL30931669 | 0.83 | MAOB (0.53) | ALOX5MEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL15877638 | 0.83 | ALOX5 (0.53) | ALOX5MEN1KMT2ACYP3A4MAOB | |
| SCHEMBL9370232 | 0.80 | MAOB (0.50) | MAOBMAOA | |
| SCHEMBL19859717 | 0.80 | LNPEP (0.56) | ALOX5MEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL15779670 | 0.79 | MAOB (0.59) | ALOX5CYP3A4MAOBMAOACYP4F2 | |
| SCHEMBL190551 | 0.79 | ALOX5 (0.53) | ALOX5CYP3A4MAOBMAOACYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975091-B2 | Pyridine derivative | ASTELLAS PHARMA INC. (JP) | 2021-04-13 | — | — | US | disclosed |
| EP-3150581-B1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2020-04-15 | — | — | EP | disclosed |
| US-20200055868-A1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2020-02-20 | — | — | US | disclosed |
| US-10421762-B2 | Pyridine derivative | ASTELLAS PHARMA INC. (JP) | 2019-09-24 | — | — | US | disclosed |
| US-20170190715-A1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2017-07-06 | — | — | US | disclosed |
| US-20170190715-A1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2017-07-06 | — | — | US | disclosed |
| EP-3150581-A1 | PYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015182686-A1 | PYRIDINE DERIVATIVE | アステラス製薬株式会社 | 2015-12-03 | — | — | WO | disclosed |
| US-8633216-B2 | Imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | SANOFI (FR) | 2014-01-21 | — | — | US | disclosed |
| EP-1861403-B1 | NOVEL IMIDAZO[1,5-A]PYRIDINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SA (FR) | 2012-05-02 | — | — | EP | disclosed |
| US-8008321-B2 | Imidazo[1,5-a]pyridin-3-yl)(3-methoxy-4-nitrophenyl)methanone; a and b fibroblast growth factor receptors (FGFR) antagonist; anticarcinogenic, antitumor: lung, breast, prostate, melanomas, gliomas; antiinflammatory, vascular smooth muscle cells: atherosclerosis, restenosis, stent and bypass complications | SANOFI-AVENTIS (FR) | 2011-08-30 | — | — | US | disclosed |
| US-20110136856-A1 | Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2011-06-09 | — | — | US | disclosed |
| CN-102050821-A | Novel imidazo [1,5-a ] pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI AVENTIS | 2011-05-11 | — | — | CN | disclosed |
| US-20080108648-A1 | Novel imidazo[1,5-a] pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-05-08 | — | — | US | disclosed |
| CN-101160309-A | Novel imidazo [1, 5-a ] pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI AVENTIS (FR) | 2008-04-09 | — | — | CN | disclosed |
| EP-1861403-A1 | NOVEL IMIDAZO[1,5-A]PYRIDINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097625-A1 | NOVEL IMIDAZO[1,5-A]PYRIDINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-AVENTIS (FR) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108648-A1 | Novel imidazo[1,5-a] pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | CYP3A5, CYP4B1, CYP3A7 | ALOX5 1219/4885MEN1 919/4885ALDH1A1 238/4885 |
| US-20200055868-A1 | PYRIDINE DERIVATIVE | LAP3, PREP, DNPEP | ALOX5 204/4885MEN1 3189/4885ALDH1A1 360/4885 |
| US-20110136856-A1 | Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | P2RX6, IL5, ATIC | ALOX5 1562/4885MEN1 1729/4885ALDH1A1 711/4885 |
| US-10975091-B2 | Pyridine derivative | LAP3, PREP, DNPEP | ALOX5 204/4885MEN1 3189/4885ALDH1A1 360/4885 |
| US-10421762-B2 | Pyridine derivative | LAP3, PREP, DNPEP | ALOX5 204/4885MEN1 3189/4885ALDH1A1 360/4885 |
| US-20170190715-A1 | PYRIDINE DERIVATIVE | LAP3, PREP, DNPEP | ALOX5 204/4885MEN1 3189/4885ALDH1A1 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.