Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533983 | 0.84 | MAPT (0.51) | MAPTPKMCYP1A2CYP2C9CTSB | |
| SCHEMBL8533986 | 0.84 | MAPT (0.51) | MAPTPKMCYP1A2CYP2C9CTSB | |
| SCHEMBL27985416 | 0.75 | MAPT (0.58) | MAPTPKMCYP1A2CYP2C9CTSB | |
| SCHEMBL2206983 | 0.73 | CTSB (0.68) | MAPTPKMCYP1A2CYP2C9CTSB | |
| SCHEMBL30779614 | 0.73 | CTSB (0.68) | MAPTPKMCYP1A2CYP2C9CTSB | |
| SCHEMBL14935499 | 0.70 | MAPT (0.69) | MAPTRAB9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9978289 | 0.70 | MAPT (0.69) | MAPTRAB9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL114440 | 0.70 | MAPT (0.58) | MAPTTDP1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL11049170 | 0.70 | MAPT (0.69) | MAPTRAB9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6194046 | 0.70 | ALDH1A1 (0.62) | MAPTCYP1A2CYP2C9TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105283454-B | Quinazoline and azepine quinazoline as RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/MTOR access double inhibitor | ASANA BIOSCIENCES, LLC (US) | 2019-10-29 | — | — | CN | disclosed |