SCHEMBL28323735

SCHEMBL28323735

Nc1nc(N)c(Cl)c(N2CCCCC2)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.56
HSD17B10 Q99714 1/20 0.43
MAP2K7 O14733 1/20 0.43
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 2/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
NUDT1 P36639 1/20 0.41
SLC9A5 Q14940 2/20 0.40
PLAU P00749 2/20 0.40
NOS1 P29475 2/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TP53 P04637 1/20 0.40
CYP2D6 P10635 1/20 0.40
TSHR P16473 1/20 0.40
SLC9A1 P19634 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA2B P29275 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9663929 0.80 LMNA (0.50) LMNAHSD17B10CYP1A2CYP2C19MAPT
Hydrochloric Acid SCHEMBL6250270 0.78 LMNA (0.49) LMNAHSD17B10CYP1A2CYP2C19MAPT
SCHEMBL17822430 0.77 LMNA (0.55) LMNAHSD17B10NOS1ALDH1A1TSHR
SCHEMBL17822445 0.77 LMNA (0.55) LMNAHSD17B10NOS1ALDH1A1TSHR
SCHEMBL9154409 0.77 LMNA (0.47) LMNAHSD17B10CYP1A2CYP2C19MAPT
SCHEMBL17979711 0.77 CHRM3 (0.49) LMNAHSD17B10CYP1A2CYP2C19MAPT
SCHEMBL31419879 0.75 LMNA (0.53) LMNAHSD17B10CYP2C19MAPTCYP2C9
Hydrochloric Acid SCHEMBL17822431 0.75 LMNA (0.53) LMNAHSD17B10NOS1ALDH1A1TSHR
SCHEMBL17822435 0.74 CTSK (0.52) LMNAHSD17B10CYP1A2CYP2C19MAPT
SCHEMBL17979709 0.74 CHRM3 (0.46) LMNAHSD17B10CYP1A2CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110327467-A The composition that is made of the auxiliary material of hydroxyl and pyrimidines and containing the pharmaceutical preparation of the composition 黄泳华 2019-10-15 CN claimed
CN-110327467-A The composition that is made of the auxiliary material of hydroxyl and pyrimidines and containing the pharmaceutical preparation of the composition 黄泳华 2019-10-15 CN disclosed