Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631782 | 0.81 | NUDT1 (0.50) | CYP1A2MAPTNUDT1CRHBPCRHR2 | |
| SCHEMBL9663929 | 0.80 | LMNA (0.50) | LMNAHSD17B10CYP2C9CYP2C19CYP1A2 | |
| Hydrochloric Acid SCHEMBL6250270 | 0.78 | LMNA (0.49) | LMNAHSD17B10CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL17822430 | 0.77 | LMNA (0.55) | LMNAHSD17B10CHUKCHRM3PDE4A | |
| SCHEMBL17822445 | 0.77 | LMNA (0.55) | LMNAHSD17B10CHUKCHRM3PDE4A | |
| SCHEMBL17979711 | 0.77 | CHRM3 (0.49) | LMNAHSD17B10CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL28323735 | 0.77 | LMNA (0.56) | LMNAHSD17B10CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL31419879 | 0.75 | LMNA (0.53) | LMNAHSD17B10CYP2C9CYP2C19MAPT | |
| Hydrochloric Acid SCHEMBL17822431 | 0.75 | LMNA (0.53) | LMNAHSD17B10CHUKCHRM3PDE4A | |
| SCHEMBL17822435 | 0.74 | CTSK (0.52) | LMNAHSD17B10CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557301-B1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS FOR PREVENTING HAIR LOSS | UPJOHN CO (US) | 1995-03-22 | — | — | EP | claimed |
| US-5373012-A | Useful in treatment of hair growth and cardiovascular disorder | THE UPJOHN COMPANY (US) | 1994-12-13 | — | — | US | claimed |
| EP-0557301-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS. | UPJOHN CO (US) | 1993-09-01 | — | — | EP | claimed |
| WO-1992008705-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1992-05-29 | — | — | WO | claimed |
| EP-0557301-B1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS FOR PREVENTING HAIR LOSS | UPJOHN CO (US) | 1995-03-22 | — | — | EP | disclosed |
| US-5373012-A | Useful in treatment of hair growth and cardiovascular disorder | THE UPJOHN COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0557301-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS. | UPJOHN CO (US) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992008705-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |