SCHEMBL28323938

SCHEMBL28323938

Cc1cc2c(cc1I)C(C=O)NCC2

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 6/20 0.36
TBXA2R P21731 5/20 0.36
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
HTR2B P41595 1/20 0.35
MAOA P21397 4/20 0.34
DRD2 P14416 2/20 0.34
TSHR P16473 2/20 0.34
KDM4E B2RXH2 1/20 0.34
CYP2C9 P11712 1/20 0.34
DRD3 P35462 1/20 0.34
HIF1A Q16665 1/20 0.34
HSD17B10 Q99714 1/20 0.34
DRD4 P21917 1/20 0.34
KMT2A Q03164 2/20 0.34
ADRB1 P08588 2/20 0.33
ADRB3 P13945 2/20 0.33
KDM1A O60341 1/20 0.33
KDM4C Q9H3R0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28770047 0.75 ADRA2A (0.41) ADRB2TBXA2RDRD2DRD4KMT2A
SCHEMBL27975898 0.75 KDM1A (0.43) MAOADRD2TSHRKDM4ECYP2C9
SCHEMBL17732723 0.75 KDM1A (0.43) MAOADRD2TSHRKDM4ECYP2C9
SCHEMBL17732769 0.75 KDM1A (0.43) MAOADRD2TSHRKDM4ECYP2C9
SCHEMBL27977413 0.74 HTR2A (0.47) HTR2AHTR2CHTR2BMAOADRD2
SCHEMBL27901805 0.74 MAOA (0.62) MAOATSHRHSD17B10KMT2AKDM4C
SCHEMBL9285411 0.70 HTR2C (0.66) HTR2AHTR2CHTR2BADRB1
SCHEMBL17732708 0.70 CA1 (0.55) HTR2AHTR2CHTR2BMAOATSHR
SCHEMBL27743619 0.70 MAOA (0.44) ADRB2MAOADRD2TSHRKDM4E
SCHEMBL17732716 0.70 CA1 (0.55) HTR2AHTR2CHTR2BMAOATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110325526-A Isoquinolin and naphthyridine compounds 伊莱利利公司 2019-10-11 CN disclosed