Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TERT | O14746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600130 | 0.86 | TERT (0.47) | MAPTTERTALDH1A1NPC1RAB9A | |
| SCHEMBL28325844 | 0.85 | ALDH1A1 (0.50) | MAPTTERTALDH1A1NPC1RAB9A | |
| SCHEMBL16179917 | 0.84 | ALDH1A1 (0.59) | MAPTTERTALDH1A1NPC1RAB9A | |
| SCHEMBL3628069 | 0.82 | NPC1 (0.61) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22005560 | 0.81 | MAPT (0.48) | MAPTTERTALDH1A1NPC1RAB9A | |
| SCHEMBL2321964 | 0.81 | SMN1; SMN2 (0.41) | MAPTTERTALDH1A1NPC1RAB9A | |
| SCHEMBL5950603 | 0.80 | NPC1 (0.59) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL805867 | 0.80 | SCN9A (0.54) | — | |
| SCHEMBL30137531 | 0.80 | ALDH1A1 (0.52) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL28325852 | 0.80 | ALDH1A1 (0.52) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110372579-A | A kind of 1- aryl -3- (6- aryl-pyridine -2- base)-propenone and the preparation method and application thereof | 南方医科大学 | 2019-10-25 | — | — | CN | disclosed |