SCHEMBL28326484

SCHEMBL28326484

OCn1nnc(-c2ccccc2Br)c1-c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
MAPK1 P28482 1/20 0.46
GRM2 Q14416 1/20 0.38
TDO2 P48775 4/20 0.38
IDO1 P14902 4/20 0.38
CDC7 O00311 1/20 0.36
MAP4K4 O95819 1/20 0.36
PIM1 P11309 1/20 0.36
PRKACA P17612 1/20 0.36
CDK2 P24941 1/20 0.36
GSK3B P49841 1/20 0.36
HIPK2 Q9H2X6 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36
MKNK2 Q9HBH9 1/20 0.36
PKM P14618 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28326474 0.82 CDC7 (0.44) MAPK1IDO1CDC7MAP4K4PIM1
SCHEMBL28327764 0.82 IDO1 (0.44) ALDH1A1TDO2IDO1CDC7MAP4K4
SCHEMBL28326472 0.82 DHODH (0.42) GRM2TDO2IDO1
SCHEMBL28326488 0.81 CYP19A1 (0.43) ALDH1A1MAPK1TDO2CDC7MAP4K4
SCHEMBL28327750 0.80 DPP4 (0.51) MAPK1TDO2IDO1CDC7MAP4K4
SCHEMBL28326482 0.80 ALDH1A1 (0.51) ALDH1A1HPGD
SCHEMBL28327749 0.78 CYP19A1 (0.44) ALDH1A1MAPK1TDO2IDO1CDC7
SCHEMBL28327761 0.75 MAPK14 (0.50) MAPK1TDO2IDO1CDC7MAP4K4
SCHEMBL28327767 0.72 ALDH1A1 (0.42) ALDH1A1CDC7
SCHEMBL28327746 0.72 CYP2E1 (0.43) MAPK1CDC7MAP4K4PIM1PRKACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110423239-A 1,3- oxazines and 1,2,3- triazole derivative and its synthetic method and application UNIV KUNMING SCIENCE & TECHNOLOGY 2019-11-08 CN disclosed