SCHEMBL28326488

SCHEMBL28326488

OCn1nnc(-c2ccc(Br)cc2)c1-c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.43
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
CDC7 O00311 2/20 0.41
MAP4K4 O95819 2/20 0.41
PIM1 P11309 2/20 0.41
PRKACA P17612 2/20 0.41
CDK2 P24941 2/20 0.41
GSK3B P49841 2/20 0.41
HIPK2 Q9H2X6 2/20 0.41
CLK4 Q9HAZ1 2/20 0.41
MKNK2 Q9HBH9 2/20 0.41
MAPK1 P28482 2/20 0.41
ALDH1A1 P00352 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
TDO2 P48775 1/20 0.41
PLK4 O00444 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28326474 0.91 CDC7 (0.44) CDC7MAP4K4PIM1PRKACACDK2
SCHEMBL28327749 0.85 CYP19A1 (0.44) CYP19A1MEN1NPC1RAB9AKMT2A
SCHEMBL28327761 0.85 MAPK14 (0.50) CDC7MAP4K4PIM1PRKACACDK2
SCHEMBL28327753 0.82 TAAR1 (0.47) CDC7MAP4K4PIM1PRKACACDK2
SCHEMBL28326484 0.81 ALDH1A1 (0.46) CDC7MAP4K4PIM1PRKACACDK2
SCHEMBL5050336 0.79 TDO2 (0.54) CYP19A1MEN1KMT2ACDC7MAP4K4
SCHEMBL5051921 0.79 TDO2 (0.54) CYP19A1MEN1KMT2ACDC7MAP4K4
SCHEMBL28327746 0.77 CYP2E1 (0.43) CDC7MAP4K4PIM1PRKACACDK2
SCHEMBL28326481 0.77 CDC7 (0.43) CDC7MAP4K4PIM1PRKACACDK2
SCHEMBL2801060 0.75 CA1 (0.55) MEN1NPC1RAB9AKMT2ACDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110423239-A 1,3- oxazines and 1,2,3- triazole derivative and its synthetic method and application UNIV KUNMING SCIENCE & TECHNOLOGY 2019-11-08 CN disclosed