Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27879283 | 0.96 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL791431 | 0.96 | — | — | |
| Piperazine SCHEMBL4260232 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL2463793 | 0.81 | — | — | |
| Piperazine SCHEMBL6685072 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27557138 | 0.79 | — | — | |
| Propane SCHEMBL3971658 | 0.79 | HIF1A (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL11775250 | 0.79 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL27896621 | 0.79 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL3005686 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110498903-A | Expediting setting type epoxy systems | EVONIK DEGUSSA GMBH | 2019-11-26 | — | — | CN | claimed |
| CN-110498906-A | Expediting setting type epoxy systems | EVONIK DEGUSSA GMBH | 2019-11-26 | — | — | CN | claimed |
| CN-110498903-A | Expediting setting type epoxy systems | EVONIK DEGUSSA GMBH | 2019-11-26 | — | — | CN | disclosed |
| CN-110498906-A | Expediting setting type epoxy systems | EVONIK DEGUSSA GMBH | 2019-11-26 | — | — | CN | disclosed |