Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL4260232 | 1.00 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27879283 | 0.85 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL791431 | 0.85 | — | — | |
| Piperazine SCHEMBL27476631 | 0.84 | DNM1 (0.50) | HIF1AMAPTPDE4AKDRDNM1 | |
| Piperidine SCHEMBL7523716 | 0.84 | ALDH1A1 (0.53) | CXCR4SMN1; SMN2DNM1MEN1KMT2A | |
| Piperazine SCHEMBL13281519 | 0.82 | DNM1 (0.63) | DNM1MEN1KMT2AALDH1A1TSHR | |
| Piperazine SCHEMBL28328748 | 0.81 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL2842298 | 0.81 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL14739784 | 0.81 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5946683 | 0.81 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074564-A2 | PROCESS FOR MAKING POLYAMIDE TEXTILE ARTICLES BEARING DESIGNS IN DIFFERENT COLORS | NILIT LTD. (IL) | 2004-09-02 | — | — | WO | disclosed |
| US-20030022018-A1 | Inks for electroluminescent devices and a method for preparation thereof | ELAM ELECTROLUMINESCENT INDUSTRIES LTD. | 2003-01-30 | — | — | US | disclosed |