Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 7/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.52 |
| ▸ | TYK2 | P29597 | 4/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL28328992 | 0.92 | JAK3 (0.53) | PLK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL28875981 | 0.84 | JAK3 (0.72) | PLK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL29813737 | 0.84 | JAK3 (0.72) | PLK4JAK3JAK1JAK2TYK2 | |
| Morpholine SCHEMBL28328996 | 0.84 | JAK3 (0.72) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28875985 | 0.81 | JAK3 (0.58) | PLK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL29813539 | 0.79 | JAK2 (0.71) | PLK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL28876010 | 0.79 | JAK2 (0.71) | PLK4JAK3JAK1JAK2TYK2 | |
| Morpholine SCHEMBL28329001 | 0.77 | JAK3 (0.66) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28328993 | 0.76 | JAK3 (0.53) | PLK4JAK3JAK1JAK2TYK2 | |
| SCHEMBL28876015 | 0.74 | JAK3 (0.56) | PLK4JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-A | Replace class phenyl pyrimidine derivative as jak kinase inhibitor or its pharmaceutical salt, Preparation method and use | 中国药科大学 | 2019-10-15 | — | — | CN | claimed |
| CN-110330484-A | Replace class phenyl pyrimidine derivative as jak kinase inhibitor or its pharmaceutical salt, Preparation method and use | 中国药科大学 | 2019-10-15 | — | — | CN | disclosed |