Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2832797 | 0.93 | KMT2A (0.52) | L3MBTL3KMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL4377238 | 0.91 | KMT2A (0.71) | L3MBTL3KMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL4375187 | 0.90 | KMT2A (0.73) | L3MBTL3KMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL2830376 | 0.87 | KMT2A (0.59) | L3MBTL3KMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL5456813 | 0.87 | ALDH1A1 (0.64) | KMT2AALDH1A1MEN1KDM4EATM | |
| SCHEMBL2833225 | 0.84 | KMT2A (0.80) | L3MBTL3KMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL4375522 | 0.84 | KMT2A (0.62) | KMT2AALDH1A1TSHRMEN1KDM4E | |
| SCHEMBL4384250 | 0.83 | KMT2A (0.64) | KMT2AALDH1A1TSHRMEN1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4378950 | 0.83 | KMT2A (0.61) | KMT2AALDH1A1TSHRMEN1KDM4E | |
| SCHEMBL2835539 | 0.83 | KMT2A (0.60) | L3MBTL3KMT2AALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |