Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377262 | 0.91 | KMT2A (0.66) | KMT2AKDM4EPOLBSIGMAR1MEN1 | |
| SCHEMBL4382131 | 0.89 | KMT2A (0.68) | KMT2AKDM4EPOLBSIGMAR1MEN1 | |
| SCHEMBL2833221 | 0.87 | L3MBTL3 (0.59) | KMT2AKDM4EMEN1L3MBTL3ALDH1A1 | |
| SCHEMBL2833225 | 0.81 | KMT2A (0.80) | KMT2AKDM4EMEN1L3MBTL3ALDH1A1 | |
| SCHEMBL2832797 | 0.81 | KMT2A (0.52) | KMT2AKDM4EMEN1L3MBTL3ALDH1A1 | |
| SCHEMBL2835539 | 0.79 | KMT2A (0.60) | KMT2AKDM4EPOLBSIGMAR1MEN1 | |
| SCHEMBL13090086 | 0.79 | ALDH1A1 (0.69) | KMT2AKDM4EPOLBL3MBTL3ALDH1A1 | |
| SCHEMBL10771524 | 0.79 | KDM4E (0.63) | KMT2AKDM4EPOLBMEN1ALDH1A1 | |
| SCHEMBL2830939 | 0.79 | KMT2A (0.58) | KMT2AKDM4EPOLBSIGMAR1MEN1 | |
| SCHEMBL4377238 | 0.78 | KMT2A (0.71) | KMT2AKDM4EMEN1L3MBTL3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |