Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CBX7 | O95931 | 1/20 | 0.52 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.52 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.50 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.50 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378416 | 0.91 | ALDH1A1 (0.73) | KMT2AALDH1A1TSHRSIGMAR1MAPT | |
| SCHEMBL4376335 | 0.90 | ALDH1A1 (0.76) | KMT2AALDH1A1TSHRSIGMAR1MAPT | |
| SCHEMBL22813680 | 0.88 | SIGMAR1 (0.62) | ALDH1A1SIGMAR1TDP1HRH3KDM4E | |
| SCHEMBL2833225 | 0.86 | KMT2A (0.80) | KMT2AALDH1A1TSHRMEN1L3MBTL3 | |
| SCHEMBL2833221 | 0.83 | L3MBTL3 (0.59) | KMT2AALDH1A1TSHRMEN1L3MBTL3 | |
| SCHEMBL20988914 | 0.81 | PKM (0.53) | ALDH1A1TSHRSIGMAR1MAPTTPSAB1 | |
| SCHEMBL8326447 | 0.81 | SIGMAR1 (0.66) | KMT2AALDH1A1MEN1SIGMAR1MAPT | |
| SCHEMBL8324239 | 0.80 | FKBP1A (0.72) | KMT2AALDH1A1MEN1SIGMAR1KDM4E | |
| SCHEMBL13624853 | 0.80 | SIGMAR1 (0.61) | KMT2AALDH1A1MEN1SIGMAR1MAPT | |
| SCHEMBL20989033 | 0.79 | SIGMAR1 (0.50) | KMT2AALDH1A1TSHRSIGMAR1TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |