Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28958230 | 0.77 | NPC1 (0.38) | HPGDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18526971 | 0.75 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL865202 | 0.71 | CRHBP (0.32) | — | |
| SCHEMBL28334784 | 0.71 | DHODH (0.39) | NPC1RAB9ASMN1; SMN2MAPTKDR | |
| SCHEMBL14833277 | 0.71 | MAPK1 (0.52) | KDRFGFR3 | |
| SCHEMBL19924588 | 0.68 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20456886 | 0.68 | HPGD (1.00) | HPGD | |
| SCHEMBL31038422 | 0.68 | HPGD (1.00) | HPGD | |
| SCHEMBL6232953 | 0.68 | CRHBP (0.32) | — | |
| SCHEMBL5438885 | 0.68 | NPC1 (0.54) | HPGDNPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573154-A | Compositions and methods for modulating short-chain dehydrogenase activity | 卡斯西部储备大学 | 2019-12-13 | — | — | CN | disclosed |