SCHEMBL28337052

SCHEMBL28337052

NC1(N)C=CC(C(=O)Nc2c(Cl)cccc2Cl)=CC1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
TYK2 P29597 1/20 0.42
POLB P06746 1/20 0.42
PLA2G1B P04054 1/20 0.38
ATG4B Q9Y4P1 1/20 0.38
MAPT P10636 2/20 0.37
JAK2 O60674 1/20 0.36
JAK1 P23458 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14972669 0.85 CYP1A2 (0.48) KMT2AMEN1
SCHEMBL28879787 0.75 MEN1 (0.50) KMT2AMEN1LMNAPOLBMAPT
SCHEMBL28068398 0.68 GRM4 (0.31)
SCHEMBL28669837 0.67 MGLL (0.37) MAPT
SCHEMBL28159138 0.66 CES2 (0.45) LMNAPOLBMAPT
Benzophenone SCHEMBL28991975 0.66 ALDH1A1 (0.45) KMT2AMEN1LMNAPOLBMAPT
SCHEMBL28110404 0.65 CYP2A6 (0.35) LMNA
SCHEMBL1439894 0.64 TYK2 (0.52) KMT2AMEN1LMNATYK2POLB
Methane SCHEMBL27338097 0.64 CYP2A6 (0.34) LMNA
SCHEMBL28652067 0.64 PTPN1 (0.44) KMT2AMEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110628025-B Polyimide precursor, polyimide, and material for use in production thereof 宇部兴产株式会社 2022-07-12 CN disclosed
CN-110628025-A Polyimide precursor, polyimide, and material for use in preparation thereof 宇部兴产株式会社 2019-12-31 CN disclosed