Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | CA3 | P07451 | 2/20 | 0.31 |
| ▸ | CA5A | P35218 | 2/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2018659 | 0.85 | ALDH1A1 (0.36) | FAAHKMT2AALDH1A1 | |
| SCHEMBL1790228 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL10795924 | 0.83 | MCL1 (0.50) | MCL1FAAHKMT2ATERTDPP4 | |
| Trifluoroacetic Acid SCHEMBL31245497 | 0.81 | DNM1 (0.44) | HDAC4HDAC1HDAC6KDM4ECA12 | |
| Trifluoroacetic Acid SCHEMBL3651032 | 0.81 | FFAR3 (0.35) | HDAC1KMT2AEPHX1TLR7ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2587874 | 0.81 | MCL1 (0.34) | MCL1FAAHHDAC4HDAC1HDAC6 | |
| SCHEMBL21153346 | 0.81 | MCL1 (0.48) | MCL1FAAHKMT2ATERTDPP4 | |
| Trifluoroacetic Acid SCHEMBL2242176 | 0.80 | TP53 (0.44) | FAAHHDAC1KMT2AEPHX1POLB | |
| Trifluoroacetic Acid SCHEMBL23387488 | 0.78 | MAOA (0.35) | HDAC1TLR7 | |
| Trifluoroacetic Acid SCHEMBL13519111 | 0.78 | MCL1 (0.38) | MCL1FAAHHDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-110668988-A | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2020-01-10 | — | — | CN | disclosed |