Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.64 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | QDPR | P09417 | 4/20 | 0.45 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28458164 | 0.93 | ACMSD (0.57) | ACMSDKMOKDM4EGLAHTT | |
| SCHEMBL28454797 | 0.93 | ACMSD (0.57) | ACMSDKMOKDM4EGLAHTT | |
| SCHEMBL7069626 | 0.93 | ACMSD (0.57) | ACMSDKMOKDM4EGLAHTT | |
| SCHEMBL917464 | 0.93 | ACMSD (0.57) | ACMSDKMOKDM4EGLAHTT | |
| SCHEMBL10884357 | 0.93 | ACMSD (0.57) | ACMSDKMOKDM4EGLAHTT | |
| SCHEMBL10890219 | 0.93 | ACMSD (0.57) | ACMSDKMOKDM4EGLAHTT | |
| SCHEMBL7069800 | 0.91 | ACMSD (0.56) | ACMSDKMOTDP1HDAC8HDAC4 | |
| SCHEMBL11026644 | 0.86 | ACMSD (0.50) | ACMSDTDP1HDAC8HDAC4HDAC2 | |
| SCHEMBL930211 | 0.84 | QDPR (0.52) | ACMSDKDM4EHIF1ATDP1QDPR | |
| SCHEMBL20503312 | 0.80 | ACMSD (0.64) | ACMSDKMOKDM4EGLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787258-A | Molded articles comprising post-consumer recycled polycarbonate and methods of making the same | 高新特殊工程塑料全球技术有限公司 | 2022-07-22 | — | — | CN | claimed |
| CN-111133036-A | Method for producing flame-retardant polycarbonate pellets and flame-retardant polycarbonate pellets produced thereby | 沙特基础工业全球技术有限公司 | 2020-05-08 | — | — | CN | claimed |
| CN-106457782-B | Method for additive manufacturing using thermoplastic material having a selected melt index | 沙特基础工业全球技术有限公司 | 2019-12-10 | — | — | CN | claimed |
| CN-118181904-A | Multilayer polymeric film and method of making the same | 沙特基础工业全球技术有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-114787258-A | Molded articles comprising post-consumer recycled polycarbonate and methods of making the same | 高新特殊工程塑料全球技术有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113195636-A | Polycarbonate compositions and related articles and additive manufacturing methods | 高新特殊工程塑料全球技术有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-111133036-B | Method for producing flame-retardant polycarbonate pellets and flame-retardant polycarbonate pellets produced thereby | 沙特基础工业全球技术有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-110214160-B | Polycarbonate with improved carbon fiber-matrix interface | 沙特基础工业全球技术有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-109070570-B | Thermoformable mask and method of using same | 沙特基础工业全球技术有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107257819-B | Emulsion process for making ultrafine spherical polymer particles | 沙特基础工业全球技术有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-107429054-B | Flame retardant compositions, methods of manufacture thereof, and articles comprising the same | 沙特基础工业全球技术有限公司 | 2020-06-19 | — | — | CN | disclosed |
| CN-111133036-A | Method for producing flame-retardant polycarbonate pellets and flame-retardant polycarbonate pellets produced thereby | 沙特基础工业全球技术有限公司 | 2020-05-08 | — | — | CN | disclosed |
| CN-110959055-A | Aqueous polymer dispersion, method for producing same, and sized fiber bundle | 沙特基础工业全球技术有限公司 | 2020-04-03 | — | — | CN | disclosed |
| CN-110709733-A | Multilayer polymer film and method of making same | 沙特基础工业全球技术有限公司 | 2020-01-17 | — | — | CN | disclosed |
| CN-107531988-B | Flame retardant compositions, methods of making, and articles comprising the same | 沙特基础工业全球技术有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-110655773-A | Copolycarbonate compositions and articles derived therefrom | 沙特基础工业全球技术有限公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-106457782-B | Method for additive manufacturing using thermoplastic material having a selected melt index | 沙特基础工业全球技术有限公司 | 2019-12-10 | — | — | CN | disclosed |