Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.59 |
| ▸ | GRK2 | P25098 | 6/20 | 0.55 |
| ▸ | GRK5 | P34947 | 6/20 | 0.55 |
| ▸ | FLT3 | P36888 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29631680 | 1.00 | MET (0.59) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL28343404 | 0.92 | MET (0.59) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL29631682 | 0.86 | MET (0.64) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL28346361 | 0.86 | MET (0.64) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL21776583 | 0.85 | MET (0.59) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL29631656 | 0.85 | MET (0.59) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL16758516 | 0.77 | MET (0.58) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL16758552 | 0.76 | MET (0.66) | METGRK2GRK5FLT3JAK2 | |
| SCHEMBL18861159 | 0.76 | MET (0.57) | METGRK2GRK5JAK2JAK1 | |
| SCHEMBL30387867 | 0.76 | MET (0.57) | METGRK2GRK5JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520416-B | Polysubstituted pyridone derivative, preparation method and medical application thereof | 北京越之康泰生物医药科技有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-110520416-A | Polysubstituted pyridine ketones derivant, preparation method and its medical usage | BEIJING YUEZHIKANGTAI BIOMEDICINES CO LTD | 2019-11-29 | — | — | CN | disclosed |