Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 7/20 | 0.34 |
| ▸ | SYK | P43405 | 7/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 6/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30209592 | 1.00 | PIK3CD (0.36) | PIK3CDPIK3C3MAPK13MAPK12MAPK11 | |
| SCHEMBL28343115 | 0.74 | PIK3CD (0.37) | PIK3CDPIK3C3MAPK13MAPK12MAPK11 | |
| SCHEMBL28345339 | 0.72 | CDK4 (0.30) | — | |
| SCHEMBL28342721 | 0.72 | LMNA (0.44) | MAPK13MAPK12MAPK11MAPK14CDK2 | |
| SCHEMBL30209582 | 0.72 | LMNA (0.44) | MAPK13MAPK12MAPK11MAPK14CDK2 | |
| SCHEMBL28345474 | 0.70 | KDM4E (0.39) | NPC1RAB9AKDM4EALDH1A1GLA | |
| SCHEMBL30209584 | 0.70 | KDM4E (0.39) | NPC1RAB9AKDM4EALDH1A1GLA | |
| SCHEMBL12410773 | 0.69 | NPSR1 (0.45) | NPC1RAB9AALDH1A1 | |
| SCHEMBL23244457 | 0.67 | PLK1 (0.43) | MAPK13PIM1GSK3BSYKCDK2 | |
| SCHEMBL3653788 | 0.67 | DKK1 (0.52) | MAPK13MAPK12MAPK11MAPK14CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110655509-B | 2-aminopyrimidine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-110684020-B | 2-aminopyrimidine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-110684020-A | 2-aminopyrimidine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-01-14 | — | — | CN | disclosed |
| CN-110655509-A | 2-aminopyrimidine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-01-07 | — | — | CN | disclosed |