Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | STAT3 | P40763 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | SDHB | P21912 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | BPTF | Q12830 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30209584 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1RAB9ATP53STAT3 | |
| SCHEMBL21621272 | 0.77 | ALDH1A1 (0.58) | KDM4EALDH1A1RAB9ATP53STAT3 | |
| SCHEMBL30107948 | 0.77 | ALDH1A1 (0.58) | KDM4EALDH1A1RAB9ATP53STAT3 | |
| SCHEMBL28822645 | 0.73 | KDM4E (0.35) | KDM4EALDH1A1RAB9ATP53STAT3 | |
| SCHEMBL30209582 | 0.73 | LMNA (0.44) | KDM4EALDH1A1NPSR1HPGDHTT | |
| SCHEMBL28342721 | 0.73 | LMNA (0.44) | KDM4EALDH1A1NPSR1HPGDHTT | |
| SCHEMBL4138614 | 0.71 | NPSR1 (0.42) | KDM4EALDH1A1RAB9ATP53STAT3 | |
| SCHEMBL30637352 | 0.71 | NPSR1 (0.42) | KDM4EALDH1A1RAB9ATP53STAT3 | |
| SCHEMBL2199521 | 0.71 | GRM4 (0.59) | KDM4EALDH1A1RAB9ATP53HPGD | |
| SCHEMBL3580841 | 0.71 | MAP4K4 (0.43) | KDM4EALDH1A1RAB9ATP53STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110655509-B | 2-aminopyrimidine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-110684020-A | 2-aminopyrimidine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-01-14 | — | — | CN | disclosed |
| CN-110655509-A | 2-aminopyrimidine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-01-07 | — | — | CN | disclosed |