Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837029 | 0.96 | OPRM1 (0.33) | OPRM1LMNAOPRL1SCN9ANAAA | |
| SCHEMBL2834822 | 0.94 | OPRM1 (0.32) | OPRM1OPRL1NAAABDKRB1 | |
| SCHEMBL2831143 | 0.91 | LMNA (0.32) | LMNASCN9ANAAAPOLBBDKRB1 | |
| SCHEMBL2835310 | 0.90 | BDKRB1 (0.33) | OPRM1LMNAOPRL1NAAABDKRB1 | |
| SCHEMBL2834659 | 0.87 | OPRM1 (0.32) | OPRM1LMNAOPRL1NAAABDKRB1 | |
| SCHEMBL2834661 | 0.87 | OPRM1 (0.37) | OPRM1LMNAOPRL1POLB | |
| SCHEMBL2837025 | 0.86 | OPRM1 (0.32) | OPRM1LMNAOPRL1ROCK1ROCK2 | |
| SCHEMBL2840074 | 0.86 | LMNA (0.35) | OPRM1LMNAOPRL1SCN9ANAAA | |
| SCHEMBL2832814 | 0.86 | LMNA (0.33) | LMNABDKRB1 | |
| SCHEMBL2837027 | 0.86 | OPRM1 (0.36) | OPRM1LMNAOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8269000-B2 | Substituted pyrimidine and triazine compounds | GRUENENTHAL GMBH (DE) | 2012-09-18 | — | — | US | claimed |
| US-20100173889-A1 | Substituted Pyrimidine and Triazine Compounds | GRUENENTHAL GMBH (DE) | 2010-07-08 | — | — | US | claimed |
| US-8269000-B2 | Substituted pyrimidine and triazine compounds | GRUENENTHAL GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20100173889-A1 | Substituted Pyrimidine and Triazine Compounds | GRUENENTHAL GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173889-A1 | Substituted Pyrimidine and Triazine Compounds | ADORA2B, CCNB1, TYMS | OPRM1 1056/4885LMNA 3222/4885OPRL1 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.