Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28348308 | 0.91 | HDAC6 (0.65) | HPGDHIF1ALMNAMAPTMAPK1 | |
| SCHEMBL11114421 | 0.89 | HPGD (0.67) | HPGDLMNAMAPTHDAC1HDAC3 | |
| SCHEMBL3436397 | 0.86 | HPGD (0.68) | HPGDLMNAMAPTHDAC1HDAC3 | |
| SCHEMBL28598419 | 0.86 | HPGD (0.63) | HPGDLMNAMAPTHDAC1HDAC3 | |
| SCHEMBL28606195 | 0.85 | HIF1A (0.78) | HPGDHIF1AMAPTHDAC8HDAC6 | |
| SCHEMBL28348350 | 0.84 | P2RX7 (0.58) | HPGDHIF1ALMNAMAPTHDAC1 | |
| SCHEMBL7703958 | 0.83 | IRAK4 (0.66) | HPGDHIF1ALMNAMAPTMEN1 | |
| SCHEMBL2555278 | 0.81 | HPGD (0.72) | HPGDLMNAMAPTHDAC1HDAC3 | |
| SCHEMBL11910582 | 0.81 | MAPT (0.64) | HPGDHIF1ALMNAMAPTHDAC1 | |
| SCHEMBL10272754 | 0.80 | HPGD (0.66) | HPGDLMNAMAPTHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110407824-B | Aryl formamide compound and preparation method, pharmaceutical composition and application thereof | 安徽医科大学 | 2021-07-02 | — | — | CN | disclosed |
| CN-110407824-A | Aryl methanamide compounds and preparation method thereof, pharmaceutical composition and purposes | UNIV ANHUI MEDICAL | 2019-11-05 | — | — | CN | disclosed |