Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28348308 | 0.93 | HDAC6 (0.65) | IRAK4MAPTTP53HDAC6TLR7 | |
| SCHEMBL17175809 | 0.88 | IRAK4 (0.69) | IRAK4MAPTTP53HDAC6TLR7 | |
| SCHEMBL28344825 | 0.86 | IRAK4 (0.68) | IRAK4MAPTTP53HDAC6TLR7 | |
| SCHEMBL28601973 | 0.85 | HDAC6 (0.69) | IRAK4MAPTTP53HDAC6TLR7 | |
| SCHEMBL28348018 | 0.83 | HPGD (0.63) | MAPTHDAC6ALDH1A1HDAC2HIF1A | |
| SCHEMBL11910582 | 0.82 | MAPT (0.64) | MAPTTP53HDAC6TLR7ALDH1A1 | |
| SCHEMBL28970478 | 0.80 | HDAC6 (0.78) | IRAK4MAPTHDAC6TLR7ALDH1A1 | |
| Chlorobenzene SCHEMBL28344826 | 0.80 | HDAC2 (0.67) | IRAK4MAPTTP53HDAC6TLR7 | |
| SCHEMBL2113234 | 0.79 | HDAC6 (0.67) | IRAK4MAPTTP53HDAC6TLR7 | |
| SCHEMBL3477450 | 0.79 | HDAC6 (0.67) | IRAK4MAPTHDAC6TLR7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |